The word collagen alludes to healing and bonding. It is derived from the Greek words kolla (glue) and gennao (I produce). A "producer of glue" is a suitable portrayal of collagen as this intercellular structural protein plays a fundamental role in holding the body together.
Collagen is the main protein in the skin and most powerful protein in our system. It represents 60% of the total skin content and 30% of all whole body protein content.. Its highest quantities occur in the skin, skeletal system, organ of sight, kidneys, liver and alimentary tract. The extracellular matrix, known as ECM, in which the body is submerged contains collagen which flows around the organs, supplementing existing structural defects.
The main function of collagen is to give the skin flexibility, tone and elasticity, as well as to moisturize and to stimulate. It is found in the dermis layer storing and releasing water to maintain the optimum texture level and constant renewal of cells, thus preventing wrinkles and stretch marks from forming. Collagen is produced by fibroblasts, the cells of connective tissues. The turnover of collagen occurs throughout the life of a human organism. Its renewal cycle is every 140-160 days - worn out collagen degrades and shortages are replaced.
Over 20 types of collagen occur naturally in the human organism. Collagen type I, is the most abundant collagen in human body and is known to maintain the integrity of the dermis and ECM. Aging skin is admittedly related to the reduction of collagen type I. The synthesis of this type of collagen in skin takes place not only in fibroblasts, but also in the keratinocyte layer of the epidermis.
From age 25 onwards, the natural supplies of collagen weaken and become less productive. The body begins to lose its ability to create new collagen, losing collagen at a rate of 1.5% per annum. Free radicals and toxins destroy collagen fibers, and reducing levels of copper, vitamin A, C or E in the body adversely affect the natural production of collagen. The lack of new collagen leads to a host of symptoms associated with aging: sagging, fine lines, wrinkles, dryness, discoloration and uneven skin tone.
SKINTIMES effectively delivers biologically active marine collagen deep into the skin to support ECM and stimulate fibroblast cells proliferation and mass collagen synthesis in dermis.
SKINTIMES has developed a technologically advanced extraction process involving an extraordinary delicate mechanism process of hydrolyzing Marine Collagen to breakdown the molecular bonds between individual collagen strands by use of slowly finessed chemical reaction and multiphase filtration. Key to this process is maintaining stable temperatures under 95°F to ensure a small molecular structure of the extracted collagen, enabling its absorption by the skin and flow deep down the skin layers.
SKINTIMES Marine Collagen bears characteristics that are essential to naturally complement and stimulate the human collagen synthesis, supplementing any deficiencies and initiating the process of skin regeneration.
SKINTIMES Marine Collagen is a ‘living’ biologically active protein able to effectively (1) retain a triple helix structure outside its natural environment, (2) achieve a metabolic process, (3) penetrate deep into skin, (4) deposit soluble native collagen and (5) reinforce ECM by boosting the synthesis of collagen and nourish the underlying structures of the skin.
Upon transdermal application and skin absorption, SKINTIMES Marine Collagen spirals break down and EMC is immediately enriched by the supply in abundance of key amino acids, glycine, proline and hydroxyproline, and other active ingredients that activate the function in the skin of fibroblasts and keratinocytes. Consequently, pro-collagen formed in the fibroblasts is synthesized into helices.
SKINTIMES Marine Collagen’s triple helix structure has a triple boosting effect on skin’s own collagen synthesis:
When the SKINTIMES Marine Collagen is applied to the skin immediately after the face is cleansed while the pores are open for maximum assimilation of the collagen into the lower layers of the skin, it enriches the ECM of all the layers of the skin with amino acids, which facilitates fibroblast activity. At the same time, it increases the organism’s production of its own collagen.
Once applied on the skin, the enzyme collagenase breaks down collagen’s molecular structure. As a result the denaturation temperature (temperature above or below the range in which cells tend to live that will cause proteins to unfold or "denature") for the triple helix structure decreases, allowing it to unravel at body temperature, and then enzymes such as elastase and gelatinase break down the unraveled helix into lower molecular weight compounds (extracellular route). At the same time, another route is used, in which collagen is taken into cells like macrophages (defense cells) and broken down in those cells.
Because collagen from other sources and other processes melts at a much higher temperature, it often sits on the skin without melting or being absorbed. The processing of Skintimes Marine Collagen allows for a lower molecular weight and lower denaturation rate which enables its molecular structure to easily melt on the skin and be gradually absorbed.
For the extracellular space (everything outside a cells, excluding ECM), the ECM is a collagen ‘factory’ of fibroblasts, chondrocytes and keratinocytes freeing the polypeptide amino acid chains. It is here, with the help of ascorbic acid (Vitamin C) as an activator, the amino acid sequence twists into helices. The ECM is reinforced when it is infused with peptides which are absorbed and dissolved on their way through the high capacity layers of the marine collagen spirals - ultimately increasing the amount of collagen in the ECM.